Optimal foraging theory has been criticized for underestimating patch exploitation time. However, proper modeling of costs not only answers these criticisms, but it also explains apparently irrational behaviors like the sunk-cost effect. When a forager is sure to experience high initial costs repeatedly, the forager should devote more time to exploitation than searching in order to minimize the accumulation of said costs. Thus, increased recognition or reconnaissance costs lead to increased exploitation times in order to reduce the frequency of future (...) costs, and this result can be used to explain paradoxical human preference for higher costs. In fact, this result also provides an explanation for how continuing a very costly task indefinitely provides the optimal long-term rate of gain; the entry cost of each new task is so great that the forager avoids ever returning to search. In general, apparently irrational decisions may be optimal when considering the lifetime of a forager within a larger system. (shrink)

The Toronto experience suggests that there may be several general lessons for academic health sciences complexes to learn from the Olivieri/Apotex affair regarding the ethics, independence, and integrity of clinical research sponsored by for profit enterprises. From a local perspective, the OAA occurred when there already was a focus on the complex and changing relationships among the University of Toronto, its medical school, the fully affiliated teaching hospitals, and off campus faculty because of intertwined interests and responsibilities. The OAA became (...) a catalyst that accelerated various systemic reforms, particularly concerning academic/industry relations. In this article, the evolving governance framework for the Toronto academic health sciences complex is reviewed and these policy and process reforms discussed. These reforms have created collaborative activity among research ethics boards and contract research offices of the partner institutions, and allowed the joint university/hospital ethics centre to play a role in governance and policy, while respecting the missions and mandates of the involved institutions. Although few of the policies are dramatically innovative, what is arguably novel is the elaboration of an overarching governance framework that aims to move ethics to a central focus in the academic complex. Time alone will tell how sustainable and effective these changes are. (shrink)

Chronologically sequenced chapter units give an overall historical perspective in this text on ethics, while chapter introductions include biographical, historical and other information.

Surgical expertise does not have a clear definition and is often culturally associated with power, authority, prestige, and case number rather than more objective proxies of excellence. Multiple models of expertise progression have been proposed including the Dreyfus model, however, they all currently require subjective evaluation of skill. Recently, efforts have been made to improve the ways in which surgical excellence is measured and expertise is defined using artificial intelligence, video recordings, and accelerometers. However, these aforementioned methods of assessment are (...) still subjective or indirect proxies of expertise, thus uncovering the neural mechanisms that differentiate expert surgeons from trainees may enhance the objectivity of surgical expertise validation. In fact, some researchers have already suggested that their neural imaging-based expertise classification methods outperform currently used methods of surgical skill certification such as the Fundamentals of Laparoscopic Surgery scores. Such imaging biomarkers would not only help better identify the highest performing surgeons, but could also improve residency programs by providing more objective, evidence-based feedback and developmental milestones for those in training and perhaps act as a marker of surgical potential in medical students. Despite the potential advantages of using neural imaging in the assessment of surgical expertise, this field of research remains in its infancy. This systematic review identifies studies that have applied neuromonitoring in assessing surgical skill across levels of expertise. The goals of this review are to identify the strongest neural indicators of surgical expertise, the limitations of the current literature on this subject, the most sensible future directions for further study. We found substantial evidence that surgical expertise can be delineated by differential activation and connectivity in the prefrontal cortex across multiple task and neuroimaging modalities. Specifically, novices tend to have greater PFC activation than experts under standard conditions in bimanual and decision-making tasks. However, under high temporal demand tasks, experts had increased PFC activation whereas novices had decreased PFC activation. Common limitations uncovered in this review were that task difficulty was often insufficient to delineate between residents and attending. Moreover, attending level involvement was also low in multiple studies which may also have contributed to this issue. Most studies did not analyze the ability of their neuromonitoring findings to accurately classify subjects by level of expertise. Finally, the predominance of fNIRS as the neuromonitoring modality limits our ability to uncover the neural correlates of surgical expertise in non-cortical brain regions. Future studies should first strive to address these limitations. In the longer term, longitudinal within-subjects design over the course of a residency or even a career will also advance the field. Although logistically arduous, such studies would likely be most beneficial in demonstrating effects of increasing surgical expertise on regional brain activation and inter-region connectivity. (shrink)

At long last a comprehensive tool in English for a better understanding of the most basic terms in Aristotle's philosophy. A careful comparison of the original Greek, medieval and renaissance Latin translations and a reappraisal of English usage make the work a definitive source for the precise grasp of what has been the historical Aristotle as far as the documents permit one to judge. -- provided by the publisher.

Background In the ethical and clinical literature, cases of parents who want treatment for their child to be withdrawn against the views of the medical team have not received much attention. Yet resolution of such conflicts demands much effort of both the medical team and parents. Objective To discuss who can best protect a child9s interests, which often becomes a central issue, putting considerable pressure on mutual trust and partnership. Methods We describe the case of a 3-year-old boy with acquired (...) brain damage due to autoimmune-mediated encephalitis whose parents wanted to stop treatment. By comparing this case with relevant literature, we systematically explored the pros and cons of sharing end-of-life decisions with parents in cases where treatment is considered futile by parents and not (yet) by physicians. Conclusions Sharing end-of-life decisions with parents is a more important duty for physicians than protecting parents from guilt or doubt. Moreover, a request from parents on behalf of their child to discontinue treatment is, and should be, hard to over-rule in cases with significant prognostic uncertainty and/or in cases with divergent opinions within the medical team. (shrink)

One often hears a complaint about “bare particulars”. This complaint has bugged me for years. I know it bugs others too, but no one seems to have vented in print, so that is what I propose to do. (I hope also to say a few constructive things along the way.) The complaint is aimed at the substratum theory, which says that particulars are, in a certain sense, separate from their universals. If universals and particulars are separate, connected to each other (...) only by a relation of instantiation, then, it is said, the nature of these particulars becomes mysterious. In themselves, they do not have any properties at all. They are nothing but a pincushion into which universals may be poked. They are Locke’s “I know not what” (1689, II, xxiii, §2); they are Plato’s receptacles (Timaeus 48c–53c); they are “bare particulars”.1 Against substratum theory there is the bundle theory, according to which particulars are just bundles of universals. The substratum and bundle theories agree on much. They agree that both universals and particulars exist. And they agree that a particular in some sense has universals. (I use phrases like ‘particular P has universal U ’ and ‘particular P ’s universals’ neutrally as between the substratum and bundle theories.) But the bundle theory says that a particular is exhaustively composed of (i.e., is a mereological fusion of) its universals. The substratum theory, on the other hand, denies this. Take a particular, and mereologically subtract away its universals. Is anything left? According to the bundle theory, no. But according to the substratum theory, something is indeed left. Call this remaining something a thin particular. The thin particular does not contain the universals as parts; it instantiates them. (shrink)

While many are impressed with the utility of possible worlds in linguistics and philosophy, few can accept the modal realism of David Lewis, who regards possible worlds as sui generis entities of a kind with the concrete world we inhabit.1 Not all uses of possible worlds require exotic ontology. Consider, for instance, the use of Kripke models to establish formal results in modal logic. These models contain sets often regarded for heuristic reasons as sets of “possible worlds”. But the “worlds” (...) in these sets can be anything at all; they can be numbers, or people, or sh. The set of worlds, together with the accessibility relation and the rest of the model, is used as a purely formal structure.2 One can even go beyond establishing results about formal systems and apply Kripke models to English, as Charles Chihara has recently argued.3 Chihara shows, for instance, how to use Kripke models (plus primitive modal notions) to give an account of validity for English modal sentences. In other cases worlds are not really needed at all. It is often vivid to give a counterexample thus: “There is a possible world in which P. Since your theory implies that in all worlds, not-P, your theory is wrong.” But the counterexample could just as easily be given using modal operators: “Possibly, P. Since your theory implies that it is necessary that not-P, your theory is wrong.”. (shrink)

"Early in the 1960s Adorno gave four courses of lectures on the road leading to Negative Dialectics, his magnum opus of 1966. The second of these was concerned with the topics of history and freedom. In terms of content, these lectures represented an early version of the chapters in Negative Dialectics devoted to Kant and Hegel. In formal terms, these were improvised lectures that permit us to glimpse a philosophical work in progress." -- Cover, p. [4].

Le Bulletin bibliographique de philosophie politique et sociale est réalisé pour la revue Philosophique par une équipe de rédactrices et de rédacteurs. Il est coordonné par Caroline Guibet Lafaye (CNRS) et Fabien Ferri (université de Franche-Comté) au sein du Centre de Documentation et de Bibliographie Philosophiques de l’université de Franche-Comté (UR 2274 CDBP – Logiques de l’agir), et propose de brèves recensions d’ouvrages récemment parus, réparties dans diverses rubriques thématiques. P...

Using four principles common to several theories about possible worlds, It is argued that the necessary existence of a divine being that is essentially omnipotent, Omniscient, And morally perfect is impossible. The central argument employs the premise that there are possible worlds that any divine being ought not to actualize (because of their evil contents). This premise is then defended on the grounds that the same sort of justification that we give for other modal statements that we accept can be (...) given for modal statements which entail the premise. It is concluded that we must reject the guiding principle that gives rise to the traditional theistic concept, Viz., That if a property p of an individual is an excellence of it and hence its having p is good, Then its having p necessarily or essentially is better. (shrink)